Replere's Clinical Trial

A Double-Blind, Randomized, Controlled Clinical Trial Evaluating the Efficacy and Tolerance of Replere, a Phenolic Antioxidant Skin Care System Containing Coffea Arabica and Concentrated Fruit and Vegetable Extracts

Presented in part at the International Society of Antioxidants in Nutrition and Health 6th International Conference on Skin Aging and Antioxidants, October, 2009, Malta.

Presented at the Félag Islenskra Húðlækna (Icelandic Dermatological Association) meeting, January, 2011, Iceland.

Presented at the 6th World Congress on Polyphenols Applications, Paris, France, June, 2012.


A 12 week, double-blinded, randomized, controlled clinical usage study was conducted to evaluate the efficacy and tolerance of Replere, a phenolic antioxidant skin care system, to reduce the appearance of photoaging. It is because of the high Total ORACsc score of Replere that interest for this study developed to investigate the link between the use of potent, multi-ingredient, antioxidant products and the clinical reduction of the signs of photoaging.


A total of 40 female participants were randomly assigned to apply the test regimen or control regimen for 12 weeks. One group washed with Replere Deep Clean & Clarify Face Wash twice daily, applied Replere Protect & Rejuvenate Day Lotion each morning and Replere Repair & Replenish Night Crème and Replere Renew & Firm Eye Serum each evening. The second group washed with a control facial wash twice daily and applied a control moisturizer each morning and evening. Clinical evaluations for efficacy were made by a board certified dermatologist at baseline and after 6 and 12 weeks of product use. Efficacy was also measured by subjects’ self-assessments and via photography and instrumentation.


In a 12-week, double-blinded, randomized and controlled clinical study, participants using Replere showed an improvement in firmness, clarity, tactile roughness, hyperpigmentation, blotchy redness, fine lines and wrinkles and overall brightness of their skin.

100% of participants reported that their skin felt softer
96% of participants reported that the products were mild and did not irritate their skin
87% of participants reported improvement in brightness, glow and radiance
87% of participants reported healthier skin
83% of participants reported improvement of wrinkles in the eye area 
83% of participants reported more even skin tone